Available at: http://books.nap.edu/books/0309065542/html/. View abstract. J.Med.Assoc.Thai. Insufficient Evidence to Rate Effectiveness for... Vitamin D Deficiency: How Much Vitamin D Is Enough? View abstract. View abstract. View abstract. 2008;91(10):1558-1563. Schweiz.Rundsch.Med Prax. Drug Facts and Comparisons. It is also taken by mouth for dandruff, depression, diabetic nerve pain, enhancing immune function, improving athletic performance, tongue infections, gray hair, headache, hyperactivity, low blood sugar, trouble sleeping (insomnia), irritability, low blood pressure, multiple sclerosis, muscular dystrophy, leg cramps associated with pregnancy or alcoholism, general nerve pain, and obesity. View abstract. It also offers smooth and glowing skin. The recommended amount for adults is 5 mg per day. Vitamin B5, also known as pantothenic acid, is a water-soluble vitamin that is found in all living cells within the body. Eur J Appl Physiol Occup Physiol 1998;77:486-91. Patrizi, A., Neri, I., Varotti, E., and Raone, B. Early, R. G. and Carlson, B. R. Water-soluble vitamin therapy in the delay of fatigue from physical activity in hot climatic conditions. Ali, A., Njike, V. Y., Northrup, V., Sabina, A. Raczynska, K., Iwaszkiewicz-Bilikiewicz, B., and Stozkowska, W. [Gel with provitamin B5 applied during tests with the Goldmann triple-mirror]. Making sure to get enough vitamin D also helps allergy problems. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. View abstract. View abstract. Practitioner 1980;224:208-11. 2004;51(2):126-129. 2. Patients who take pantothenic acid are very prone to overdose, making patient experience vitamin b complex side effects. Mets, M. A., Ketzer, S., Blom, C., van Gerven, M. H., van Willigenburg, G. M., Olivier, B., and Verster, J. C. Positive effects of Red Bull(R) Energy Drink on driving performance during prolonged driving. SHILS ME. Pantothenic acid, also called vitamin B 5 is a water-soluble B vitamin and therefore an essential nutrient. Ophthalmologica 2009;223(6):414-418. View abstract. Inhibitory effect of omega-methylpantothenic acid. View abstract. Ivy, J. L., Kammer, L., Ding, Z., Wang, B., Bernard, J. R., Liao, Y. H., and Hwang, J. Verse, T., Klocker, N., Riedel, F., Pirsig, W., and Scheithauer, M. O. A double-blind, prospective and randomized trial. People apply dexpanthenol, which is made from pantothenic acid, to the skin for itching, promoting healing of mild eczemas and other skin conditions, insect stings, bites, poison ivy, diaper rash, and acne. All animals require pantothenic acid in order to synthesize coenzyme A (CoA) – essential for fatty acid metabolism – as well as to in general synthesize and metabolize proteins, carbohydrates, and fats.. Pantothenic acid is the combination of pantoic acid and β-alanine. Rev.Laryngol.Otol.Rhinol.(Bord.) View abstract. View abstract. 1985;7(1-2):109-114. Dermatology 1997;195(Suppl 2):57-61. Improved cycling time-trial performance after ingestion of a caffeine energy drink. Klin.Oczna 2003;105(3-4):179-181. Lokkevik E, Skovlund E, Reitan JB, et al. View abstract. 2010;76(1):20-26. 5. Mieny, C. J. J.Dermatolog.Treat. Eur.Surg.Res. Pantothenic acid or vitamin B5 is a light-yellowish viscous oil that is soluble in water and in ethanol. View abstract. [Clinical evaluation of provitamin B5 drops and gel for postoperative treatment of corneal and conjuctival injuries]. Vitamin B5 - Pantothenic Acid. PMID: 14808256 [PubMed - indexed for MEDLINE] MeSH Terms. Dosing considerations for Pantothenic Acid. 11-20-1990;79(47):1457-1462. Ercan, I., Cakir, B. O., Ozcelik, M., and Turgut, S. Efficacy of Tonimer gel spray on postoperative nasal care after endonasal surgery. Champault, G. and Patel, J. C. [Treatment of constipation with Bepanthene]. View abstract. Dosages for supplementation fall between 100mg and 500mg. View abstract. Camargo, F. B., Jr., Gaspar, L. R., and Maia Campos, P. M. Skin moisturizing effects of panthenol-based formulations. Klykov, N. V. [Use of calcium pantothenate in the treatment of chronic cardiac insufficiency]. Roper, B., Kaisig, D., Auer, F., Mergen, E., and Molls, M. Theta-Cream versus Bepanthol lotion in breast cancer patients under radiotherapy. J.Cosmet.Sci. Stomach blockage: Do not receive injections of dexpanthenol, a derivative of pantothenic acid, if you have a gastrointestinal blockage. The biosynthesis of CoA from pantothenic acid is an essential and View abstract. In high doses, pantothenic acid may inhibit the absorption of biotin produced by microflora in the large intestine; diarrhea may occur. Vitamin B5, also called pantothenic acid, is one of the most important vitamins for human life. Dexpanthenol is given with a needle in to the vein or muscle to improve intestinal movement (intestinal peristalsis), possibly following surgery of the gut, for abdominal bloating (distension) due to reduced intestinal function, and for gas following surgery or pregnancy. D. Nohr, H.K. Herbst, R. A., Uter, W., Pirker, C., Geier, J., and Frosch, P. J. Allergic and non-allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5-year period. Pantothenic acid is a component of Coenzyme A and also the acyl carrier protein (ACP) of fatty acid synthase (see Chapter 9: Lipids on lipids for many reactions involving CoA). 2002;3(6):427-433. Int J Sport Nutr Exerc Metab 2009;19(1):61-78. Effects of megavitamin therapy on children with attention deficit disorders. Pantothenic acid is not known to interact or interfere with any medicines. Br.J.Dermatol. HNO 2004;52(7):611-615. eMedicineHealth does not provide medical advice, diagnosis or treatment. View abstract. Pantothenic Acid Laryngorhinootologie 2000;79(3):151-154. II. View abstract. J.Nutr.Sci.Vitaminol. This can result in severe diarrhea. It helps alleviate the symptoms of asthma and allergy. Arnold LE, Christopher J, Huestis RD, Smeltzer DJ. Pantothenic acid supplementation may reduce allergic reactions, especially allergic rhinitis.One trial on over 100 patients with allergic rhinitis given 250mg of pantothenic acid twice daily found that the majority had almost instant relief. Minerva Pediatr. Shibata, K., Fukuwatari, T., Watanabe, T., and Nishimuta, M. Intra- and inter-individual variations of blood and urinary water-soluble vitamins in Japanese young adults consuming a semi-purified diet for 7 days. Strahlenther.Onkol. S.Afr.J.Surg. For instance, omega-3, whether taken as a supplement or through foods, helps a great deal in diminishing eczema symptoms and even allergy symptoms in general. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. Kehrl, W., Sonnemann, U., and Dethlefsen, U. View abstract. A report from the General Practitioner Research Group. J.Med.Assoc.Thai. View abstract. Webster MJ. Allergy sufferers may find pantothenic acid beneficial for controlling the nasal congestion that can develop during an allergic reaction. Biro, K., Thaci, D., Ochsendorf, F. R., Kaufmann, R., and Boehncke, W. H. Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Int.Z.Angew.Physiol 1969;27(1):43-50. Pantothenic acid is LIKELY SAFE for most people when taken by mouth in appropriate amounts. Eur.J.Pediatr. 4. Pantothenic acid restores hydration and makes the skin soft and supple. View abstract. Creme or powder? 1995;27(3):158-166. Schreck, U., Paulsen, F., Bamberg, M., and Budach, W. Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Becker-Schiebe, M., Mengs, U., Schaefer, M., Bulitta, M., and Hoffmann, W. Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients. It protects the outer layer of the skin against damage caused by environmental toxins. (Tokyo) 2009;55(6):459-470. 1998 ed. Brzezinska-Wcislo, L. [Evaluation of vitamin B6 and calcium pantothenate effectiveness on hair growth from clinical and trichographic aspects for treatment of diffuse alopecia in women]. 1983;33(5):792-795. It helps prevent early aging and promotes physical growth. People take pantothenic acid for treating dietary deficiencies, acne, alcoholism, allergies, baldness, asthma, attention deficit-hyperactivity disorder (ADHD), autism, burning feet syndrome, yeast infections, heart failure, carpal tunnel syndrome, breathing problems, celiac disease, colitis, pink eye (conjunctivitis), seizures, and bladder infections. Bergler, W., Sadick, H., Gotte, K., Riedel, F., and Hormann, K. Topical estrogens combined with argon plasma coagulation in the management of epistaxis in hereditary hemorrhagic telangiectasia. According to ‘Biochemical, Physiological and Molecular Aspects of Human Nutrition,’ the single most important nutrient for adrenal gland function is pantothenic acid; insufficient levels of pantothenic acid reduce the necessary amounts of cortisone from being secreted.’. Wolff, H. H. and Kieser, M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Proksch, E. and Nissen, H. P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. View abstract. Your email address will not be published. B., Williams, A. L., Liberti, L. S., Perlman, A. I., Adelson, H., and Katz, D. L. Intravenous micronutrient therapy (Myers' Cocktail) for fibromyalgia: a placebo-controlled pilot study. 500mg per day often produces satisfactory results. Kehrl, W. and Sonnemann, U. 2004;180(5):315-322. Marquardt, R., Christ, T., and Bonfils, P. [Gelatinous tear substitutes and nonspecific eye ointments in the critical care unit and in perioperative use]. ORL J.Otorhinolaryngol.Relat Spec. Med.Chir Dig. 1994;116(7):375-384. In: Shils ME, Olson JA, Shike M, eds. Pantothenic acid is quite effective in treating nasal congestion caused by allergy. Interestingly, there is a possibility that pantothenic acid deficiency could be involved in allergies. Psychopharmacology (Berl) 2011;214(3):737-745. Smolle, M., Keller, C., Pinggera, G., Deibl, M., Rieder, J., and Lirk, P. Clear hydro-gel, compared to ointment, provides improved eye comfort after brief surgery. Washington, DC: National Academy Press, 2000. Hemophila: Do not take dexpanthenol, a derivative of pantothenic acid, if you have hemophila. J Am Diet Assoc 1998;98:699-706. 2006;89(10):1654-1658. View abstract. Gobbels, M. and Gross, D. [Clinical study of the effectiveness of a dexpanthenol containing artificial tears solution (Siccaprotect) in treatment of dry eyes]. Tantilipikorn, P., Tunsuriyawong, P., Jareoncharsri, P., Bedavanija, A., Assanasen, P., Bunnag, C., and Metheetrairut, C. A randomized, prospective, double-blind study of the efficacy of dexpanthenol nasal spray on the postoperative treatment of patients with chronic rhinosinusitis after endoscopic sinus surgery. View abstract. Biesalski, in Reference Module in Food Science, 2016. Thus, the Na + or Ca 2+ salts of panthenol are usually used in pharmaceutical preparations. Strahlenther.Onkol. Acta Oncol 1996;35:1021-6. 2007;59(1):23-28. The adrenal glands, which sit atop the kidneys, are particularly relevant to allergic reactions because they secrete the hormones during an immune response, such as cortisone. View abstract. 1933;55(7):2912-27. See Additional Information. The effects of megadoses of selected B complex vitamins on children with hyperkinesis: controlled studies with long-term follow-up. 1972;10(2):103-105. Waterloh, E. and Groth, K. H. [Objectification of the efficacy of an ointment for joint injuries using a volumetric method]. Pantothenic acid is frequently used in combination with other B vitamins in vitamin B complex formulations. Pantothenic acid deficiency and conjugation reactions. [Clinical evaluation of the efficacy and tolerability of the ''NoAll Bimbi Pasta Trattante'' barrier cream in napkin dermatitis]. Skin treatment with bepanthen cream versus no cream during radiotherapy-a randomized, controlled trial. Strahlenther.Onkol. View abstract. 2007;51(2):239-243. View abstract. 2011;187(8):485-491. Specifically, as DigitalNaturopath.com describes, allergy sufferers who take pantothenic acid supplements before bed often find that their nasal stuffiness clears and they aren't awakened by excess mucus, stuffiness, or other allergy symptoms during the night. View abstract. View abstract. Haslock, D. I. and Wright, V. Pantothenic acid in the treatment of osteoarthrosis. Brenner A. Jerajani, H. R., Mizoguchi, H., Li, J., Whittenbarger, D. J., and Marmor, M. J. Biological Phenomena* Pantothenic Acid* Physiological Phenomena* Vitamin B Deficiency* Substances. G.Ital.Dermatol.Venereol. Like other B vitamins, pantothenic acid plays a role in nutrient degradation reactions for energy production. Pantothenic Acid, Vitamin B5 for Acne ... CoA is used at the cellular level for fatty acid oxidation and in many other biochemical reactions in the cell. Williams RJ, Lyman CM, Goodyear GH, Truesdail JH, Holaday D. "Pantothenic acid," a growth determinant of universal biological occurrence. Mammals and some microbes lack the enzyme for this synthetic step, and so, they are unable to synthesize pantothenic acid and need to obtain it from outside (23, 30). View abstract. 1. Yates AA, Schlicker SA, Suitor CW. The vitamin is a smart choice during allergy season, when it can be safely taken along with more conventional remedies. Anon. People take pantothenic acid for treating dietary deficiencies, acne, alcoholism, allergies, baldness, asthma, attention deficit-hyperactivity disorder , autism, burning feet syndrome, yeast infections, heart failure, carpal tunnel syndrome, breathing problems, celiac disease, colitis, pink eye (conjunctivitis), seizures, and bladder infections. View abstract. View abstract. Pantothenic acid or vitamin B5 is a promising water-soluble B-complex vitamin that helps in reducing facial acne lesions. Zentralbl.Gynakol. Coenzyme-A is also used during the production of cholesterol, hemoglobin, brain chemicals and hormones, especially from the adrenal glands. Pantothenic acid is needed to form coenzyme-A (CoA), and is thus critical in the metabolism and synthesis of carbohydrates, proteins, and fats. Food and Nutrition Board, Institute of Medicine. [Advance in therapy of acute rhinitis--comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis]. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Haslam RH, Dalby JT, Rademaker AW. It might increase the risk of bleeding. The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial. Keep out of reach of children. 1971;11(1):10-13. It is widely found in both plants and animals including meat, vegetables, cereal grains, legumes, eggs, and milk. Pantothenic acid is a vitamin, also known as vitamin B5. Hautarzt 1993;44(6):380-384. View abstract. 1998;174(3):149-155. Its name is derived from the Greek pantothen meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every food, with high amounts in whole grain cereals, legumes, eggs, meat, and royal jelly. Coenzyme-A is also used during the production of cholesterol, hemoglobin, brain chemicals and hormones, especially from the adrenal glands. But taking larger amounts increases the chance of having side effects such as diarrhea. Pantothenic acid is important for our bodies to properly use carbohydrates, proteins, and lipids and for healthy skin. View abstract. View abstract. Laryngorhinootologie 1998;77(9):506-512. Value of the prophylactic mouth rinsing with PVP-iodine solution]. Kehrl, W. and Sonnemann, U. 2002;111(3 Pt 1):222-228. Daeschlein, G., Alborova, J., Patzelt, A., Kramer, A., and Lademann, J. Kinetics of physiological skin flora in a suction blister wound model on healthy subjects after treatment with water-filtered infrared-A radiation. View abstract. Med.Chir Dig. View abstract. View abstract. Wiad.Lek. Fooanant, S., Chaiyasate, S., and Roongrotwattanasiri, K. Comparison on the efficacy of dexpanthenol in sea water and saline in postoperative endoscopic sinus surgery. Following are the health benefits of pantothenic acid: 1. View abstract. 1997;72(7):616-620. It is found in living cells as a coenzyme A (CoA), which is vital to numerous chemical reactions, according to a study published in the journal Vitamins and Hormones. A randomized double-blind study. 2011;62(4):361-370. Vitamin B complex generally includes vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid. Does pantothenic acid accelerate the return of bowel motility in post-operative patients? Your email address will not be published. Taking additional B5 increases the amount of Coenzyme A available for use in the cell. Gehring, W. and Gloor, M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. J.Altern.Complement Med. Castello, M. and Milani, M. Efficacy of topical hydrating and emollient lotion containing 10% urea ISDIN(R) plus dexpanthenol (Ureadin Rx 10) in the treatment of skin xerosis and pruritus in hemodialyzed patients: an open prospective pilot trial. Plesofsky-Vig N. Pantothenic acid. Vaxman, F., Olender, S., Lambert, A., Nisand, G., Aprahamian, M., Bruch, J. F., Didier, E., Volkmar, P., and Grenier, J. F. Effect of pantothenic acid and ascorbic acid supplementation on human skin wound healing process. Kardiologiia. What other names is Pantothenic Acid known by? Contact Dermatitis 2004;51(1):13-19. 2007;166(9):943-948. The metabolism of fats, carbs, and protein all rely to varying degrees on CoA. Wananukul, S., Limpongsanuruk, W., Singalavanija, S., and Wisuthsarewong, W. Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study. Abstract. A., Rahn, R., Bottcher, H. D., Schafer, V., Reimer, K., and Fleischer, W. [Prevention of radiochemotherapy-induced mucositis. Ebner, F., Heller, A., Rippke, F., and Tausch, I. Topical use of dexpanthenol in skin disorders. Costa, S. D., Muller, A., Grischke, E. M., Fuchs, A., and Bastert, G. [Postoperative management after cesarean section--infusion therapy and role of intestinal stimulation with parasympathomimetic drugs and dexpanthenon]. [Improving wound healing after nose surgery by combined administration of xylometazoline and dexpanthenol]. Rahn R, Adamietz IA, Boettcher HD, et al. View abstract. Children:Dexpanthenol, a derivative of pantothenic acid, is POSSIBLY SAFE for children when applied to the skin. Budde, J., Tronnier, H., Rahlfs, V. W., and Frei-Kleiner, S. [Systemic therapy of diffuse effluvium and hair structure damage]. Ann.Otol.Rhinol.Laryngol. View abstract. St. Louis, MO: Facts and Comparisons, 1998. View abstract. Debourdeau PM, Djezzar S, Estival JL, et al. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). 3. 2011;146(5):321-325. Or, you can get pantothenic acid in food rich in the nutrient, including organ meats, fatty fish, shellfish, yeast, egg yolks, avocado, spinach, broccoli, mushrooms, and dairy products. Laryngorhinootologie 2003;82(4):266-271. [Martin W.On treating allergic disorders. View abstract. Pantothenic acid is a precursor of coenzyme A which is required for acetylation (acyl group activation) reactions in gluconeogenesis, in the release of energy from carbohydrates, the synthesis and degradation of fatty acids, and the synthesis of sterols and steroid … Indian J.Dermatol.Venereol.Leprol. It is also applied topically for preventing and treating skin reactions to radiation therapy. Acta Anaesthesiol.Scand. View abstract. The majority of these events were mild GI complaints.16 Livestrong.com also discusses pantothenic acid in relation to allergies, and describes the nutrient's effect on allergies as follows: ‘Pantothenic acid is needed to make coenzyme-A, which is necessary for certain chemical reactions to generate energy from carbohydrates, fats and proteins. Petri, H., Pierchalla, P., and Tronnier, H. [The efficacy of drug therapy in structural lesions of the hair and in diffuse effluvium--comparative double blind study]. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives. 2002;146(6):983-991. Required fields are marked *. 1980;9(1):79-81. Are there any interactions with pantothenic acid that I should know about? It works great for hair loss. Mayo Clin.Proc. Vitamin B5, also known as pantothenic acid, can also ease allergies. J Learn Disabil 1982;15:258-64. pantothenic acid by enzymatically combining pantoic acid with β-alanine. A great many enzymes (at least 70) require CoA or ACP rendering pantothenate critical in the metabolism of carbohydrates, fats, and proteins and the functioning of the citric acid cycle. View abstract.